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All currently marketed anti-diabetic drugs targeting DPP-4 block substrate binding by making hydrogen bonds with the anchoring residues Glu205/Glu206 and occupying the S1 hydrophobic pocket (Figure 7)
A new generation of pharmacotherapies have been developed which combine GLP-1R agonism with other metabolic hormones into a single molecule
Lancet 2018;392:1519-29
ArticlePubMed 62
26 Immediate Consequence: The essentially a copy restriction snapped back into place
Microbiome (2017) 51:43
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