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Diabetes Metab Res Rev (2010) 26(4):28796
Notable modifications of MT1 over alpha-MSH include the substitution of methionine and L-phenylalanine at the fourth and seventh positions with norleucine and D-phenylalanine, respectively
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Studies using high-performance liquid chromatography (HPLC) confirm that MT-1 degradation accelerates sharply after day 28, with potency dropping to 7080% by day 35
In this regard, GLP-1 attracts attention as a possible connecting and integrating link between metabolic disorders and brain diseases
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