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In particular, MMP-9 is known to boost angiogenesis and stimulate tumor neovasculature by increasing the bioavailability of VEGF [248]
It is metabolized into several peptide fragments, primarily involving proline-rich sequences, and eliminated with a half-life under 30 minutes
The warmth many patients feel during treatment reflects this increased blood flow
Cav-1 directly interacts with eNOS and holds eNOS on an inactive status in caveolae
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