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Springer, Dordrecht, pp 621655

Pilozzi A, Carro C, Huang X (2021) Roles of -endorphin in stress, behavior, neuroinflammation, and brain energy metabolism

Researchers should conduct all studies using appropriate controls, validated methodologies, and approved experimental procedures to ensure the integrity, accuracy, and reproducibility of results

While existing research has confirmed that dysregulated expression of copper transporters (such as ATP7A, CTR1) is a core mechanism inducing cellular cuproptosis in models of endothelial injury induced by disturbed blood flow ( Drawing upon the known property of exosomes to targetedly deliver bioactive molecules, we raise a speculative hypothesis: exosomes released by damaged endothelium might have the theoretical capacity to induce secondary cuproptosis responses in the vascular microenvironment, potentially by encapsulating abnormal copper transporters or cytotoxic lipoylated protein aggregates

Additionally, quercetin modulates cellular signaling pathways involved in oxidative stress

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