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One viewer had this to say after trying a semaglutide, which is a GLP-1 agonist: I tried semaglutide and ended up in bed for five days with a huge headache, nausea, throwing up, and stomach pain
long-acting injectables may still exert effects for weeks, so timing should reflect residual activity
Nauck MA, Meier JJ
Hunt B, McConnachie CC, Gamble C, Dang-Tan T
The peptide was studied in an osteoporosis-mimicking model (glucocorticoid-induced bone loss in adult rats), where it enhanced bone formation (PMID: 11735244)
Protecting Muscle & Bone Mass About 20%, up to 40% (Spreckley 2026) of total weight lost can come from muscle tissuesomething especially concerning for women in perimenopause or menopause, who are already losing lean mass with age
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