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3.3 T-reg cells Lactate accumulation induced by tumor cells suppresses effector T cells (which lack lactate-utilizing capacity) while supporting Treg function, enabling tumor cells to evade immune clearance

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In animal studies, DSIP demonstrated anxiolytic effects, reducing anxiety-like behavior in mice (Shekunova et al., 2002), and lowering plasma corticosterone levels in rats (Kovalzon et al., 1997)

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10.1210/endo.141.7.7578 18 BuiguesA.MarchanteM.de Miguel-GmezL.MartinezJ.CervellI.PellicerA.et al (2021)

The data were presented as the fold increase of the target gene expression, normalized to the housekeeping gene beta-actin, compared to unstimulated conditions