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Currently, there is no direct evidence that GLP-1RA use contributes to progression of pancreatic cysts to PDAC, but this remains an important knowledge gap for future investigations considering the high prevalence of pancreatic cysts in the general population (~ 10% by age 50 and ~25% by age 70) 56

Behavioral tests in mice Baseline heat sensitivity was assessed to evaluate the systemic effects of glucose or GLP-1(736) administration via a hot plate apparatus (Ugo Basile, Italy)

vegans and vegetarians, due to inadequate iron intake and the lower bioavailability of iron from plants

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