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Beni-Suef Univ J Basic Appl Sci 11:60

Overactivated HER2 signaling results in increased HIF-1 and VEGF expression, which in turn activate the downstream kinase FKBP-rapamycin-associated protein (FRAP), therefore contributing to tumor progression by mediating angiogenesis and metabolic adaptation (221)

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The high circulating insulin then drives your ovaries to overproduce testosterone and tells your liver to stop making sex hormone-binding globulin (SHBG) a protein in your blood that binds up loose testosterone so it stays inactive (Diamanti-Kandarakis & Dunaif 2012)