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The mechanism by which GLP-1 RAs potentially increase suicide or suicide attempts is unclear but may involve an overactivation of the hypothalamic-pituitary-adrenal (HPA) axis [7], rapid weight loss [8], and reduced expression of brain-derived neurotrophic factor which may link weight changes to heightened anxiety and suicidal risk [9]
Until the GLP-1 shortage ends, drugmakers will have to balance commercial impact of this parallel marketplace against legal costs of winning trademark infringement, and larger drug patent / IP disputes
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Crosstalk between astrocytes and microglia: An overview