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Protocol 2: significant weight loss (20-25% body weight) Goal: Substantial weight reduction for health improvement Tirzepatide approach: Full escalation to 10-15 mg Expect to reach target dose by week 17-21 Weight loss at 15 mg: approximately 22.5% at 72 weeks Plateau typically occurs around weeks 60-72 Retatrutide approach: Full escalation to 8-12 mg Expect to reach target dose by week 13-17 Weight loss at 12 mg: 24.2% at 48 weeks, 28.7% at 68 weeks No plateau observed in trial data at 48 or 68 weeks For significant weight loss goals, retatrutide reaches 20%+ body weight reduction faster and ultimately achieves a higher ceiling

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The problem with this strategy is that it has an abysmal success rate of around 1%

This four-phase herbal protocol follows the same physiological arc that has drawn athletes and biohackers to BPC-157: soothing the gut lining, rebuilding connective tissue, modulating inflammation, and supporting vascular flow

Jeffrey Egler, Noom's Chief Medical Officer, puts it: "We set out to virtually eliminate side effects for the vast majority, so that more than 70% of people would encounter no side effects." How does it work

(2023a)