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T.NickelK.et al (2014)
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The most common adverse effects are gastrointestinal in nature, reflecting the medication's mechanism of action on GLP-1 and GIP receptors in the digestive system
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
For the majority of patients, gastrointestinal side effectsthe most common categorytypically peak during the first 48 weeks of treatment or following dose escalation, then gradually diminish over subsequent weeks as physiological adaptation occurs
This thoughtful approach is gaining serious momentum, particularly in North America, which is on track to hold 73.8% of the global semaglutide market share by 2025 thanks to proactive healthcare approaches
