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NNMT sits between NAD+ metabolism and one-carbon methylation metabolism, pathways that support redox reactions, DNA repair, and transcriptional regulation

As a direct antioxidant, redox buffer, and essential enzymatic cofactor, GSH supports mitochondrial integrity, facilitates detoxification, modulates immune responses, and contributes to the repair of oxidative damage

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Additionally, a phase 2 trial of patients with type 2 diabetes has shown tirzepatide improves cardiovascular biomarkers [59, 60]