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Researchers are still studying the effects of GLP-1 RAs during early pregnancy

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About this article Cite this article Castelhano, F.V.D., Almeida, C.A.d., Braz, G.d.A

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The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance