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The non-coenzyme action of thiamine in neurotransmission is further supported by the action of the thiamine analog oxythiamine, whose diphosphorylated derivative (oxyThDP), formed by TPK in vivo , is an antagonist of the coenzyme action of thiamine

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Clearly, more research is needed to address this gap in knowledge on the role of maternal periconceptional and gestational interventions in managing childhood obesity, particularly in humans