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Mild discomfort during activity that resolves within an hour afterward is generally acceptable

Depletion and other background things as you mention are possible, as well as the B-Vits triggering some detox that has been waiting

It also stimulates collagen and elastin synthesis through fibroblast activation, and its copper-chelating properties contribute to antioxidant defense by modulating copper-dependent superoxide dismutase activity

10.3389/fcell.2021.797339 124 YauR.RapeM

The collagen fibers are realigning

sclerotiorum to parasitize tissues of Brassica species despite the production of toxic metabolites (Rahmanpour et al., 2009)