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Although PF-05231023 demonstrated pharmacodynamic effects when dosed weekly or twice-weekly in humans, the unmodified N- and C-termini of the FGF21 moities resulted in a short (approximately 8 h) half-life for the intact C-terminal domain of FGF21 (183)

During this time, hormonal fluctuations become dramatic and can cause physical and mental changes in women

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Clin Cancer Res 1(6):583-90, 1995

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