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Conversely, while the metabolic burden in the reproductive subtype is relatively lighter, ovulatory dysfunction and hyperandrogenic symptoms are more prominent, suggesting that the mode of benefit may differ in these patients ( 2.2 Obesity and IRhyperandrogenism axis: pathophysiological hub In PCOS, obesityparticularly visceral adiposityinitiates a complex pathophysiological cascade

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The result was severe nausea, vomiting, dehydration, and in some cases hospitalization for acute pancreatitis or dangerously low blood sugar

Glycine is a conditionally essential amino acid that supports protein synthesis and glutathione production in the body

This heterodimer binds ARE sequences in target gene promoters, inducing transcription of antioxidant and cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), glutathione S-transferases (GSTs), and -glutamylcysteine synthetase (-GCS) (Jayakumar et al