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For most patients at 0.5 mg who have not achieved treatment goals, the appropriate next step is increasing to 1 mg weekly after at least four weeks at the current dose, provided the medication is well-tolerated

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Beta-arrestin recruitment and receptor internalization vary between agonists at this receptor, and the relationship between internalization rate and sustained signaling is still argued

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When glucose levels rise, CRF levels decline with the opposite occurring when glucose levels fall