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Results: The 18-month risk for ION was 8.5 versus 5.5 per 10 000 among GLP-1RA users versus SGLT2i users (RD, 3.0 [95% CI, 0.4 to 5.7]) and 7.8 versus 4.2 per 10 000 among GLP-1RA users versus DPP4i users (RD, 3.6 [CI, 1.1 to 6.1])

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The results, however, did more than just highlight a new breed of shoppers that have been changed by how accessible dramatic weight loss has been in recent years

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no human clinical safety data exists for the KLOW formulation