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The original research described it as a hepatocyte growth factor (HGF) mimetic with substantial potency in animal models of cognitive impairment
Patients with hypothyroidism have increased intestinal permeability and leaky gut phenomenon, which makes the metabolic products of bacteria such as LPS and bacterial fragments easily translocate into the circulatory system, thus activating innate immunity (Tomov et al., 2005)
Beta carotene, through its antioxidant activity, can enhance the skins defense against UV-induced oxidative stress when administered orally
The research was not especially glamorous
Given that APR-246 is currently in clinical development, these results may have implications for its use as an anticancer agent
Susan Spratt, an endocrinologist and senior medical director for the Population Health Management Office at Duke Health in North Carolina, told NBC News the results were "disheartening." "People who are rich can afford to pay the $1,000 per month for this medication," she said
