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Bianchi, Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis

Here is the concern

Key Distinctions and Synergy: GHRH amplifies existing GH signals, whereas GHRP initiates GH release, often producing shorter but faster pulses

Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines

Mitochondrial processing peptidase regulates PINK1 processing, import and parkin recruitment

Key Takeaways Protein is the priority 2535 g per meal, 80160 g daily depending on body weight Hydration is non-negotiable 2.53 litres of fluid daily, even without thirst 45 small meals work better than 3 large ones on Ozempics slowed gastric emptying Avoid fried, ultra-processed, fizzy, and alcoholic items these worsen every common side effect Resistance training from week one protects against muscle loss and metabolic slowdown Fibre (2535 g) prevents constipation build up gradually with adequate water The medication does part of the work diet and lifestyle determine the rest References Wilding JPH, et al