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While anabolic or anti-catabolic agents - especially myostatin/activin pathway inhibitors - show promise, translation into improved patient-centered outcomes is not yet established (Table 3)

PDE-5i, phosphodiesterase-5 inhibitor

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GLP-3 peptide is informal shorthand for a triple agonist, usually retatrutide, that activates GLP-1, GIP, and glucagon receptors

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