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In addition, increased permeability of both capillaries and the BBB is observed in the ischemic core, the penumbra, and other areas, resulting in perivascular and perineuronal edema

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This makes it difficult to obtain circulating factors that meet the requirements of experimental research and clinical treatment, which affects the accuracy of the research results and the therapeutic effects in the clinic

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Consequently, ANOSIM testing was also performed, which showed that clustering by treatment group was significant in each of the diversity measures (unweighted UniFrac: R value = 0.369, p = 0.0010

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