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Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]
Because tirzepatide is a dual-acting peptide that activates both GLP-1 and GIP receptors simultaneously
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In summary, a comprehensive analysis of 19 kinase candidates, which integrated LC-MS/MS data from several co-immunoprecipitations, in silico modeling, RNAi screening, and consensus sequence validation, identified KIN-19 as the most promising kinase candidate for further investigation
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