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102 Taken SG3299 as an example, formed by conjugated the DNA-binding pyrrolobenzodiazepine (PBD) payload SG3249 (tesirine) was to an v 6 -specific 20mer peptide from foot-and-mouth disease virus (FMDV) VP1 capsid protein, this v 6 -targeted PDC SG3299 demonstrated significantly greater toxicity (up to 78-fold) against v 6 -expressing cells compared to the non-targeted PDC SG3511 at equimolar doses

Glutathione is the major free radical scavenger in the brain, lower levels of this antioxidant elevate cellular vulnerability to oxidative stress

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UA suppresses carnitine palmitoyl transferase 1B (CPT1B), thereby inhibiting FA transport into the mitochondrial inner matrix for elimination

24 The oxidative stress and the increase of IOP also causes upregulation of ubiquitin (Ub) and stimulation of the Ub-proteasome pathway: 8, 25 this possibly derives from the activation of the apoptotic program

Lancet 2018;392:2180-93.ArticlePubMed 127