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Finkelstein JD, Harris BJ, Martin JJ: Methionine metabolism in mammals: Concentrations of metabolites in rat tissues

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In the Phase 2 trial, participants lost up to 24 percent of body weight over 48 weeks at the highest dose

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Patients typically receive injections once or twice weekly for the first two weeks, followed by monthly maintenance doses, making the treatment cost-effective for those requiring consistent B12 supplementation