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Transwell migration and invasion assays were performed using a 24-well transwell chamber with matrix gel as described previously [35]

Tolerance Issues on Restart: A significant concern raised by obesity experts is the potential for individuals to experience severe gastrointestinal side effects if they stop the medication for an extended period and then attempt to restart at their previous dose

In some populations, it is present in ~50% of adults[301]

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Exendin-4, a stable synthetic form of GLP-1, is commonly used clinically for diabetes treatment because GLP-1 has a short half-life (Drucker and Nauck, 2006

Meanwhile, other pharma companies are desperately trying to claw back market share of obesity drugs, which is expected to reach $150 billion by 2030