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In semaglutide, DPP-4 resistant GLP-1 is conjugated to a fatty acid chain of 18 carbon atoms, a natural ligand of albumin 93
It also serves as a required substrate for two important families of enzymes: the sirtuins, which help regulate healthy cellular aging, and the PARPs, which help repair damaged DNA
While the physical benefits are clear, people have noticed changes in mood while on semaglutide, leading to discussions about its impact on mental health
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Thank you to Rebecca Hoffman for providing input on the study design
PMID 18495806
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