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In preclinical models, apelin enhances glucose uptake in skeletal muscle via activation of AMP-activated protein kinase, improves insulin sensitivity, and increases mitochondrial oxidative capacity, supporting its role as an endogenous insulin-sensitizing hormone (Dray et al., 2008)

It does this by slowing gastric emptying and enhancing signals of fullness, making it easier to feel satisfied with smaller portions

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Best delivery method: GHK-Cu via subcutaneous injection or topical

Standard dosing begins at 2.5 mg weekly, with escalation every four weeks up to 15 mg weekly based on clinical tolerance and therapeutic response