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In 1985, Wade and colleagues reported one instance of contact between a nerve fiber and an enteroendocrine cell, refraining from using the term synapse and concluding that no evidence for direct (i.e., synaptic) innervation of enteroendocrine cells was found in this study of the adult mouse duodenum 55
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The problem usually gets worse if blood sugar levels improve very quickly, which can sometimes happen with strong diabetes medicines
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