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This organized healing process leads to tissue repair that more closely resembles normal skin architecture

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Week 1: 50mcg nightly Week 2: 100mcg nightly (if Week 1 tolerated well) Weeks 3-4: 150mcg nightly (if no adverse effects) Weeks 5-8: 200-300mcg nightly (target maintenance dose) Gradual titration helps identify your minimum effective dose while avoiding unnecessary exposure to higher amounts

The most compelling research endpoints involve mortality and disease incidence tracked over years, as demonstrated in the long-term follow-up studies showing reduced mortality in treated groups

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Researchers designing new protocols should treat earlier findings as hypothesis-generating rather than conclusive