Clinicians should evaluate for contraindications specific to GLP-1 receptor agonists, including: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or gallbladder disease Severe gastroparesis or gastrointestinal disease History of suicidal ideation or behavior Pregnancy or planned pregnancy (pregnancy testing when appropriate) Diabetic retinopathy (requires monitoring in patients with diabetes) Baseline investigations should include TSH, free T4, complete metabolic panel, lipid profile, and hemoglobin A1c (if diabetic or prediabetic)
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Hydration as First-Line Constipation Prevention Increasing water intake is the simplest and most effective first step for managing semaglutide-related constipation
Combining compounds can change effects, risks, and expectations
For GH peptides, IGF-1 drifts back down over about a month after stopping, but body-composition gains are largely kept if training and protein continue
CYB5R3 also plays a wider role in sustaining redox balance
