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Benefits: Needle-Free: Oral administration eliminates the need for injections, making it more appealing for patients with needle phobia

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Both accelerate cell turnover, and using them together can overwhelm the skin

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Semaglutide and tirzepatide are GLP-1 receptor agonists (tirzepatide also targets GIP receptors) approved for weight management and type 2 diabetes

We chose (EAAAK) 3 rigid helical linkers to work because we believe their rigidity allows for the separation of the protein domains and improves the functionality of individual domains 58,59 when compared to flexible linkers, which appear to be suitable for linking normally connected domains in a single genetic construct, such as antibody domains in scFvs 60