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The heterozygous loss of SLC25A51 modestly decreases mitochondrial NAD + content in multiple tissues and impairs liver regeneration, whereas the hepatocyte-specific overexpression of SLC25A51 is sufficient to enhance liver regeneration comparably to the effect of systemic NAD + precursor supplements
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Ashok Kumar Das, MD, FAMS, FICP, PhD, FRCP (London), is the Dean (Academic) and Professor of Medicine at Mahatma Gandhi Medical College & Research Institute, Sri Balajee Vidyapeeth, Pondicherry
Moreover, pyroptosis can induce the expression of chemokines such as CC motif chemokine ligand 2 (CCL2) [60], which activates the Akt signaling pathway and elevates -catenin levels, further driving EMT and CSC phenotypes [61]
