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While mild oxidative and inflammatory responses may correlate with atorvastatin dose, clinically significant hepatotoxicity remains largely idiosyncratic, particularly in genetically susceptible individuals

However, clinical safety depends on factors such as dosage, route of administration, individual health status, and appropriate medical supervision

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GPX4 inhibition activated ferroptosis, inducing TC cell death, rapid rise in reactive oxygen species and effectively arrested cell migration in vitro

Gudo ES, Silva-Barbosa SD, Linhares-Lacerda L, Ribeiro-Alves M, Real SC, Bou-Habib DC, Savino W