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An association between ROS levels and IFN- response in HIV-1 infection has been reported, whereby HIV-1 reverse transcriptase enzyme-induced increased ROS levels induce stronger IFN- responses 115

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If an active (reduced) glutathione stops a free radical, it itself is oxidised

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Qiu, K., Li, K., Zeng, T., Liao, Y., Min, J., Zhang, N., & Chen, L