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Disulfide cross-linking validates the physiological relevance of the closed conformation, while electron microscopy (EM) and molecular dynamic (MD) simulations suggest a large degree of conformational dynamics of ECD that is necessary for binding GLP-1

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Combination therapy with canagliflozin plus liraglutide exerts additive effect on weight loss, but not on HbA 1c , in patients with type 2 diabetes

As background, GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone in the body that affects appetite, digestion and glycemic control, which can, in turn, influence body weight and blood sugar levels

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Same thing for the 8mg groups