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Huang J, Yi H, Zhao C, Zhang Y, Zhu L, Liu B, He P, Zhou M

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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

Furthermore, from a cardiovascular point of view, metformin is known to reduce cardiovascular complications related to diabetes [53] and therefore may contribute to reducing such complications among NAFLD patients who are more prone to develop coronary, cerebrovascular, and peripheral vascular disease independently of multiple CVD risk factors [54]

Similar histologic findings can be seen in melanotic macule, and in an array of other conditions that can present as diffuse pigmentation

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