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Additionally, myocardial fibrosis, valve dysfunction and arrhythmias can also compromise systolic and diastolic function, thereby affecting cardiac output ( 2.4 Cellular dysfunction Decreased and impaired function of cardiomyocytes, including altered calcium handling and energy production (27)

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Activation of astrocytes in hippocampus decreases fear memory through adenosine a(1) receptors

It also stimulates the liver to produce insulin-like growth factor 1 (IGF-1), which promotes tissue growth, supports protein synthesis, and contributes to overall metabolic regulation

Sep 2009;81(3):182-187