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Unfortunately, this compensatory surge is futile because the downstream clearance pathwaysspecifically the enzymes mitochondrial superoxide dismutase (SOD2) and glutathione peroxidase 4 (GPX4)are severely dysfunctional
Moberly SP, Mather KJ, Berwick ZC, Owen MK, Goodwill AG, Casalini ED, Hutchins GD, Green MA, Ng Y, Considine RV, Perry KM, Chisholm RL, Tune JD: Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus
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Groundbreaking clinical trials published in late 2023 and 2024 show that semaglutide, approved in 2019 for treating diabetes and in 2021 for weight management, also reduces rates of heart disease and kidney disease, and reduces tissue and systemic inflammation
Shanu et al., 2013
It has been observed that patients with fatty liver and type 2 diabetes register histological data of greater severity than patients without diabetes [7]
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