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In the Phase 3 TRIUMPH-4 trial, a new safety signal called dysesthesia (abnormal skin sensations like tingling or burning) appeared in up to 20.9% of patients on the highest dose

In most cases, the gap comes down to what is and isn't included

Advanced dosing considerations The standard titration covers most situations

First responders and other members of the community who are exposed to excessive toxins on the job

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy

For a more detailed look at documented side effects, read our guide on glutathione supplements: uses, drug side effects, and doses