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Stimulation of the PI3K/Akt/mTOR protein synthesis pathway: Upon receptor activation, IGF-1 LR3 triggers intracellular cascades including PI3K and Akt phosphorylation

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Keywords MC4R deficiency , genetic obesity , GLP-1 receptor agonists , leptin-melanocortin pathway , weight management 0 1 INTRODUCTION Genetic obesity is broadly divided into syndromic obesity and non-syndromic obesity, both of which can be caused by monogenic, polygenic, or chromosomal abnormalities [1]

Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, Kazachkov M, et al

This is not a drug and so there are no known contradictions and precautions to be taken into consideration