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Originator Merck carried it through Phase 2 trials and a Phase 2b hip-fracture study but never filed for approval, so there is no FDA-approved prescription version

Harris, HR., et al

You might notice subtle changes such as duller skin , increased fatigue , or slower recovery from stress or illness

To compete directly with AbbVies new formulation, biosimilar developers needed to develop their own high-concentration, citrate-free versions and submit supplemental applications to the FDA a process that adds development time, cost, and regulatory delay

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Low levels of B12 can lead to: Fatigue Weakness Digestive issues Shortness of breath Numbness or tingling in the fingers and toes Difficulty walking / balance problems Cognitive impairment or memory loss A person can also have low levels of vitamin B without exhibiting any obvious symptoms