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Studies have demonstrated that DA, 5-HT, and other neurotransmitters are crucial in maintaining chemical homeostasis within the brain

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Metformin has been widely studied for its ability to improve insulin sensitivity and support overall metabolic health

The above results suggest that GLP-1 is important for inhibiting liver fat synthesis, and is likely to be related to AMPK, SERBP-1c, FAS, ACC-a, PI3K, and other signaling pathways

3,4 American Association of Clinical Endocrinology guidelines recommend treatment with GLP-1RA in T2DM patients with coexisting ASCVD, high-risk for ASCVD, heart failure, or chronic kidney disease regardless of their glycemic control due to their organ protective effects