Retatrutide titration protocol Retatrutide follows a similar monthly escalation pattern, but with different starting points and targets: Weeks 1-4: 1mg once weekly (initiation) Weeks 5-8: 2mg once weekly Weeks 9-12: 4mg once weekly Weeks 13-16: 8mg once weekly Week 17+: 12mg once weekly (maintenance) The retatrutide starting dose is lower at 1mg, reflecting the triple agonist mechanism and the need for careful GI adjustment
For example, green tea supplementation was only linked to a 1.5 pound greater weight loss than those not using green tea
SURMOUNT-1 Trial (72-Week Duration, 2,539 Participants): Average weight loss with 15 mg: 20.9% of body weight Participants losing 5%: 91% Participants losing 10%: 82% Participants losing 20%: 57% SURMOUNT-2 Trial (People with Type 2 Diabetes): Average weight loss with 15 mg: 15.7% A1C reduction: 2.0 percentage points Source: Jastreboff AM, et al
Things You Should Know Clean the injection site with alcohol and a cotton ball
Clin Gastroenterol Hepatol 2025;23:739-47.ArticlePubMed 22
Common side effects may include nausea, vomiting, or mild gastrointestinal issues, which usually improve over time as your body adjusts to the medication