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No clinical trials in humans have established short or long-term safety
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Transcription factor activity changes: GHK-Cu modulates activity of key transcription factors including NF-B (inflammation master regulator), AP-1 (stress response), Nrf2 (antioxidant response element activator), p53 (cell cycle and apoptosis regulator)
Each peptide has been examined separately in preclinical and cell-based laboratory research: BPC-157 in peptide signalling studies, TB-500 (a thymosin beta-4 fragment) in actin-binding and cytoskeletal research, and GHK-Cu in copper-dependent biochemical and regulatory pathway research
Sermorelin is added as a nightly subcutaneous injection
TB-500 is a fragment of the full-length thymosin beta-4 (43 amino acids), and the full-length TB-4 has substantially more human safety data than the fragment
