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most of the B 12 secreted in the bile is recycled via enterohepatic circulation

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Key considerations include: Proper system materials and hygienic design Thoughtful placement of sample points and instrumentation Automated monitoring and control strategies Validated sanitization approaches aligned with the selected technology When these elements are considered early in the design phase, WFI systems whether distillation-based or membrane-based are better positioned for reliable operation, simplified qualification, and long-term performance