Forman JP, Rimm EB, Stampfer MJ, Curhan GC
The right maintenance dose is the one you can sustain long-term with acceptable tolerability and continued progress
To clarify, off-label prescribing doesnt mean that a drug isnt safe or effective for the person being prescribed the medication -- it simply implies that an individual is using it for a reason other than what it was approved for
As their use has expanded dramatically in recent years, questions about long-term safety, including potential cancer risk, have become increasingly important for both patients and clinicians
Soc B Biol
EVOKE+ demonstrated that high-dose oral semaglutide engaged Alzheimers biology, producing favorable shifts in biomarkers of neurodegeneration and neuroinflammation, even though those changes did not translate into measurable clinical benefit over the trial period