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15 Early intervention is associated with procedural complications such as pain, local site infection, and tube detachment, whereas in the long-term problems such as weight loss, vitamin B12 deficiency, and polyneuropathy have been reported

B12 levels can decrease with age as well as being lower in people who have undergone weight loss surgery or suffer from Pernicious Anaemia, Crohns or Celiac disease

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The fragment retains the biologically active portion responsible for most therapeutic effects

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We will analyse the effect of vitamin B 12 separately in the following subgroups: Vitamin B 12 status: based on cobalamin (cut-off: 150 pmol/L) based on low total homocysteine (cut-off: 10 mol/L) based on low methylmalonic acid (cut-off: 0.26 mol/L) Maternal body mass index (cut-off: 18.5) Vegetarian (yes/no) Birth weight (cut-off: 2500 g) In these subgroup analyses, the differences in the effect between the levels of the subgroups will be measured by including two-way interaction terms in multiple regression models