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Retatrutides Phase 2 data suggest that the addition of a third receptor target may extend the efficacy ceiling further still, though direct head-to-head trials would be needed to draw firm comparative conclusions

Target dose levels and their clinical outcomes Clinical trials evaluated three primary maintenance dose levels: 4mg, 8mg, and 12mg weekly

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While both target similar mechanisms to aid weight loss, semaglutides extended-release formulation leads to more sustained effects and greater overall weight reduction